Tapentadol is an analgesic with a dual mode of action as a norepinephrine reuptake inhibitor and an agonist of the mu-opioid receptor. Its analgesic properties come into effect within few minutes of oral administration. Tapentadol is a new drug, being approved by the U.S. Food and Drug Administration (FDA) on the twenty sixth of August 2011, by the Therapeutic Goods Administration (TGA) of Australia on the twenty fourth of December 2010 and by the Medicines and Healthcare products Regulatory Agency (MHRA) of the UK on the fourth of February 2011. Tapentadol has been recognized as a step three analgesic on the World Health Organization (WHO) pain ladder. Tapentadol is utilized for the treatment of moderate to severe pain for chronic and acute musculoskeletal pain. Tapentadol is available in the U.S. in extended release formulations as Nucynta ER from Janssen Pharmaceuticals. Nucynta contains the (R,R) stereoisomer, which is a weak isomer in terms of opioid activity. Req...
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